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for instance, particulate matter in rapidly industrializing regions often contains higher concentrations of heavy metals (arsenic, lead) and sulfates from coal combustion, whereas pollution in Western urban centers is primarily driven by nitrate-rich vehicular emissions (45)

Similar to the hippocampus, a significant portion of cerebellar Purkinje cells in the CN group exhibited dark appearance with a significant cell shrinkage and cytoplasmatic condensation, which is indicative of cellular stress or degeneration

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Targeted therapy and ototoxicity Newer therapies aimed at specific cancer types, such as tyrosine kinase inhibitors (TKIs), have been associated with vestibular dysfunction, though their precise ototoxic mechanisms remain under investigation